Synergic effect of quinolones (Nalidixic acid, Ciprofloxacin,Norfloxacin, Pefloxacin, Levofloxacin, Gatifloxacin) and aminoglycosides(Gentamicin, Steptomycin, Neomycin, Kenamycin), beta-lactams(Penicillin derivatives, Cephalosporins) is only additive(indifferent) against Straphylococcus aureus, E. coli, P. aeruginosa, E. fecalis and Streptococcus pneumonia [Int. J. Antimicrob August,2001.Feb; 17(2): 103-7]. This combination can be given to provide activity against bacteria inadequqtely inhibited by the fluoroquinolones (Ciprofloxacin, Norfloxacin, Pefloxacin and Levofloxacin) [Neu HC. Eur. J. Clin. Microbial Infect. Dis., 1991 Apr; 10(4):255-61]. Quinolones should not be used in combination with macrolids (Azithromycin, Erythromycin), Tetracyclines, Magnesium and aluminium containing substances (Samad, M. A.2008.Anim Hus and Vet Scin: 534).
Friday, 27 November 2015
Synergy and antagonism of Ciprofloxacin with other antibiotics
Synergic effect of quinolones (Nalidixic acid, Ciprofloxacin,Norfloxacin, Pefloxacin, Levofloxacin, Gatifloxacin) and aminoglycosides(Gentamicin, Steptomycin, Neomycin, Kenamycin), beta-lactams(Penicillin derivatives, Cephalosporins) is only additive(indifferent) against Straphylococcus aureus, E. coli, P. aeruginosa, E. fecalis and Streptococcus pneumonia [Int. J. Antimicrob August,2001.Feb; 17(2): 103-7]. This combination can be given to provide activity against bacteria inadequqtely inhibited by the fluoroquinolones (Ciprofloxacin, Norfloxacin, Pefloxacin and Levofloxacin) [Neu HC. Eur. J. Clin. Microbial Infect. Dis., 1991 Apr; 10(4):255-61]. Quinolones should not be used in combination with macrolids (Azithromycin, Erythromycin), Tetracyclines, Magnesium and aluminium containing substances (Samad, M. A.2008.Anim Hus and Vet Scin: 534).
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